{"id":191917,"date":"2020-10-13T21:33:25","date_gmt":"2020-10-13T20:33:25","guid":{"rendered":"https:\/\/www.realites.com.tn\/?p=191917"},"modified":"2020-10-13T21:33:25","modified_gmt":"2020-10-13T20:33:25","slug":"formes-graves-de-covid-19-enfin-une-explication","status":"publish","type":"post","link":"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/","title":{"rendered":"Formes graves de Covid-19 : enfin une explication ?"},"content":{"rendered":"<div>Une tribune publi\u00e9e dans The Conversation revient sur l\u2019origine des formes s\u00e9v\u00e8res du Covid-19. R\u00e9cemment, l\u2019Inserm a identifi\u00e9 les premi\u00e8res causes g\u00e9n\u00e9tiques et immunologiques expliquant 15 % des formes graves.<\/div>\n<div>La r\u00e9ponse individuelle \u00e0 l\u2019infection par le virus SARS-CoV2 varie consid\u00e9rablement d\u2019une personne \u00e0 l\u2019autre. Des divergences qui interrogent la communaut\u00e9 scientifique depuis le d\u00e9but la crise sanitaire. R\u00e9cemment, une \u00e9tude men\u00e9e par des chercheurs de l\u2019Inserm, d\u2019Universit\u00e9 de Paris et de l\u2019AP-HP \u00e0 l\u2019Institut de recherche Imagine (h\u00f4pital Necker-Enfants malades AP-HP), et de l\u2019Universit\u00e9 Rockefeller et du Howard Hughes Medical Institute \u00e0 New York en collaboration avec l\u2019\u00e9quipe dirig\u00e9e par le Pr Guy Gorochov au Centre d\u2019Immunologie et des Maladies Infectieuses (Sorbonne Universit\u00e9\/Inserm\/CNRS), s\u2019est pench\u00e9e sur cette question. L\u2019\u00e9quipe de chercheurs a identifi\u00e9 les premi\u00e8res causes g\u00e9n\u00e9tiques et immunologiques expliquant 15 % des formes graves de Covid-19. \u201cCes malades ont un point commun : un d\u00e9faut d\u2019activit\u00e9 des interf\u00e9rons de type I, mol\u00e9cules du syst\u00e8me immunitaire qui ont normalement une puissante activit\u00e9 antivirale\u201d, note l\u2019Inserm.<\/div>\n<div>Dans une tribune publi\u00e9e dans The Conversation, Matthew Woodruff, immunologiste \u00e0 l\u2019universit\u00e9 Emory d\u2019Altanta, est revenu sur ce qui peut causer des formes s\u00e9v\u00e8res de Covid-19. Dans une r\u00e9cente \u00e9tude, publi\u00e9e dans la revue Nature, l\u2019immunologiste avait accr\u00e9dit\u00e9 l\u2019id\u00e9e que la lutte contre le virus \u00e9tait tout aussi importante que de pr\u00e9venir la dysr\u00e9gulation chez certains patients. Comme le raconte Matthew Woodruff, certaines \u00e9tudes cliniques ont rapport\u00e9 le d\u00e9clenchement \u201cd\u2019orages cytokiniques\u201d pendant lesquels la r\u00e9ponse immunitaire li\u00e9e au virus produit une importante quantit\u00e9 de mol\u00e9cules inflammatoires. Ce qui entra\u00eene ainsi l\u2019inflammation de multiples syst\u00e8mes d\u2019organes. \u201cChez ces patients, la r\u00e9ponse immunitaire cens\u00e9e \u00eatre protectrice serait devenue destructrice\u201d, rapporte l\u2019immunologiste. Afin de soulager cette r\u00e9ponse immunitaire, les m\u00e9decins ont eu recours \u00e0 des st\u00e9ro\u00efdes.<\/div>\n<div><\/div>\n<div dir=\"ltr\"><strong>*\u201cLe Covid-19 n\u2019est pas une maladie auto-immune\u201d<\/strong><\/div>\n<div>\u201cSaisir comment fonctionne la dysr\u00e9gulation immunitaire chez les patients atteints de Covid-19 pourrait permettre d\u2019identifier les malades chez qui ces traitements seraient les plus efficaces. Des approches plus cibl\u00e9es et plus puissantes, permettant de moduler le syst\u00e8me immunitaire, telles que celles actuellement r\u00e9serv\u00e9es aux maladies auto-immunes, pourraient m\u00eame \u00eatre envisag\u00e9es\u201d, d\u00e9taille l\u2019article de The Conversation. Avant de poursuivre : \u201cLe Covid-19 n\u2019est pas une maladie auto-immune. Les r\u00e9ponses inflammatoires de type auto-immunes que mon \u00e9quipe a d\u00e9couvertes pourraient simplement refl\u00e9ter la r\u00e9ponse normale face \u00e0 une infection virale devenue incontr\u00f4lable\u201d.<\/div>\n<div>Pour le moment, les scientifiques ne savent pas pourquoi seulement certains patients d\u00e9veloppent une si forte r\u00e9ponse. \u201cM\u00e9decins et scientifiques doivent continuer \u00e0 conjuguer leurs efforts pour construire notre arsenal th\u00e9rapeutique, en gardant \u00e0 l\u2019esprit que, dans certains cas, le contr\u00f4le de la r\u00e9ponse immunitaire pourrait \u00eatre aussi important que le contr\u00f4le du coronavirus SARS-CoV-2 lui-m\u00eame\u201d, conclut Matthew Woodruff.<\/div>\n<div style=\"text-align: right\">(Yahoo Actualit\u00e9s)<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Une tribune publi\u00e9e dans The Conversation revient sur l\u2019origine des formes s\u00e9v\u00e8res du Covid-19. R\u00e9cemment, l\u2019Inserm a identifi\u00e9 les premi\u00e8res causes g\u00e9n\u00e9tiques et immunologiques expliquant 15 % des formes graves.&hellip;<\/p>\n","protected":false},"author":60,"featured_media":191918,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[2515],"tags":[],"class_list":["post-191917","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sante"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Formes graves de Covid-19 : enfin une explication ? - R\u00e9alit\u00e9s Magazine<\/title>\n<meta name=\"description\" content=\"Une tribune publi\u00e9e dans The Conversation revient sur l\u2019origine des formes s\u00e9v\u00e8res du Covid-19. R\u00e9cemment, l\u2019Inserm a identifi\u00e9 les premi\u00e8res causes\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Formes graves de Covid-19 : enfin une explication ? - R\u00e9alit\u00e9s Magazine\" \/>\n<meta property=\"og:description\" content=\"Une tribune publi\u00e9e dans The Conversation revient sur l\u2019origine des formes s\u00e9v\u00e8res du Covid-19. R\u00e9cemment, l\u2019Inserm a identifi\u00e9 les premi\u00e8res causes\" \/>\n<meta property=\"og:url\" content=\"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/\" \/>\n<meta property=\"og:site_name\" content=\"R\u00e9alit\u00e9s Magazine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/realites.tn\/\" \/>\n<meta property=\"article:published_time\" content=\"2020-10-13T20:33:25+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/realites.com.tn\/fr\/wp-content\/uploads\/2020\/10\/COVID-Explications.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"704\" \/>\n\t<meta property=\"og:image:height\" content=\"539\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"La R\u00e9daction\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"La R\u00e9daction\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/\",\"url\":\"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/\",\"name\":\"Formes graves de Covid-19 : enfin une explication ? - R\u00e9alit\u00e9s Magazine\",\"isPartOf\":{\"@id\":\"https:\/\/realites.com.tn\/fr\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/realites.com.tn\/fr\/wp-content\/uploads\/2020\/10\/COVID-Explications.jpg\",\"datePublished\":\"2020-10-13T20:33:25+00:00\",\"author\":{\"@id\":\"https:\/\/realites.com.tn\/fr\/#\/schema\/person\/438b71c29a257d955d96d8aef42336e7\"},\"description\":\"Une tribune publi\u00e9e dans The Conversation revient sur l\u2019origine des formes s\u00e9v\u00e8res du Covid-19. R\u00e9cemment, l\u2019Inserm a identifi\u00e9 les premi\u00e8res causes\",\"breadcrumb\":{\"@id\":\"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/#primaryimage\",\"url\":\"https:\/\/realites.com.tn\/fr\/wp-content\/uploads\/2020\/10\/COVID-Explications.jpg\",\"contentUrl\":\"https:\/\/realites.com.tn\/fr\/wp-content\/uploads\/2020\/10\/COVID-Explications.jpg\",\"width\":704,\"height\":539,\"caption\":\"Corona virus\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/realites.com.tn\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Formes graves de Covid-19 : enfin une explication ?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/realites.com.tn\/fr\/#website\",\"url\":\"https:\/\/realites.com.tn\/fr\/\",\"name\":\"R\u00e9alit\u00e9s Magazine\",\"description\":\"Actualit\u00e9s de la Tunisie\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/realites.com.tn\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/realites.com.tn\/fr\/#\/schema\/person\/438b71c29a257d955d96d8aef42336e7\",\"name\":\"La R\u00e9daction\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/realites.com.tn\/fr\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/fbe9ab25fcc82b6e660ad5648f91eadb?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/fbe9ab25fcc82b6e660ad5648f91eadb?s=96&d=mm&r=g\",\"caption\":\"La R\u00e9daction\"},\"url\":\"https:\/\/realites.com.tn\/fr\/author\/realites5201\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Formes graves de Covid-19 : enfin une explication ? - R\u00e9alit\u00e9s Magazine","description":"Une tribune publi\u00e9e dans The Conversation revient sur l\u2019origine des formes s\u00e9v\u00e8res du Covid-19. R\u00e9cemment, l\u2019Inserm a identifi\u00e9 les premi\u00e8res causes","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/","og_locale":"fr_FR","og_type":"article","og_title":"Formes graves de Covid-19 : enfin une explication ? - R\u00e9alit\u00e9s Magazine","og_description":"Une tribune publi\u00e9e dans The Conversation revient sur l\u2019origine des formes s\u00e9v\u00e8res du Covid-19. R\u00e9cemment, l\u2019Inserm a identifi\u00e9 les premi\u00e8res causes","og_url":"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/","og_site_name":"R\u00e9alit\u00e9s Magazine","article_publisher":"https:\/\/www.facebook.com\/realites.tn\/","article_published_time":"2020-10-13T20:33:25+00:00","og_image":[{"width":704,"height":539,"url":"https:\/\/realites.com.tn\/fr\/wp-content\/uploads\/2020\/10\/COVID-Explications.jpg","type":"image\/jpeg"}],"author":"La R\u00e9daction","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"La R\u00e9daction","Dur\u00e9e de lecture estim\u00e9e":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/","url":"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/","name":"Formes graves de Covid-19 : enfin une explication ? - R\u00e9alit\u00e9s Magazine","isPartOf":{"@id":"https:\/\/realites.com.tn\/fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/#primaryimage"},"image":{"@id":"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/#primaryimage"},"thumbnailUrl":"https:\/\/realites.com.tn\/fr\/wp-content\/uploads\/2020\/10\/COVID-Explications.jpg","datePublished":"2020-10-13T20:33:25+00:00","author":{"@id":"https:\/\/realites.com.tn\/fr\/#\/schema\/person\/438b71c29a257d955d96d8aef42336e7"},"description":"Une tribune publi\u00e9e dans The Conversation revient sur l\u2019origine des formes s\u00e9v\u00e8res du Covid-19. R\u00e9cemment, l\u2019Inserm a identifi\u00e9 les premi\u00e8res causes","breadcrumb":{"@id":"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/#primaryimage","url":"https:\/\/realites.com.tn\/fr\/wp-content\/uploads\/2020\/10\/COVID-Explications.jpg","contentUrl":"https:\/\/realites.com.tn\/fr\/wp-content\/uploads\/2020\/10\/COVID-Explications.jpg","width":704,"height":539,"caption":"Corona virus"},{"@type":"BreadcrumbList","@id":"https:\/\/realites.com.tn\/fr\/formes-graves-de-covid-19-enfin-une-explication\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/realites.com.tn\/fr\/"},{"@type":"ListItem","position":2,"name":"Formes graves de Covid-19 : enfin une explication ?"}]},{"@type":"WebSite","@id":"https:\/\/realites.com.tn\/fr\/#website","url":"https:\/\/realites.com.tn\/fr\/","name":"R\u00e9alit\u00e9s Magazine","description":"Actualit\u00e9s de la Tunisie","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/realites.com.tn\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Person","@id":"https:\/\/realites.com.tn\/fr\/#\/schema\/person\/438b71c29a257d955d96d8aef42336e7","name":"La R\u00e9daction","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/realites.com.tn\/fr\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/fbe9ab25fcc82b6e660ad5648f91eadb?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/fbe9ab25fcc82b6e660ad5648f91eadb?s=96&d=mm&r=g","caption":"La R\u00e9daction"},"url":"https:\/\/realites.com.tn\/fr\/author\/realites5201\/"}]}},"jetpack_featured_media_url":"https:\/\/realites.com.tn\/fr\/wp-content\/uploads\/2020\/10\/COVID-Explications.jpg","jetpack_sharing_enabled":true,"views":27,"_links":{"self":[{"href":"https:\/\/realites.com.tn\/fr\/wp-json\/wp\/v2\/posts\/191917","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/realites.com.tn\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/realites.com.tn\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/realites.com.tn\/fr\/wp-json\/wp\/v2\/users\/60"}],"replies":[{"embeddable":true,"href":"https:\/\/realites.com.tn\/fr\/wp-json\/wp\/v2\/comments?post=191917"}],"version-history":[{"count":0,"href":"https:\/\/realites.com.tn\/fr\/wp-json\/wp\/v2\/posts\/191917\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/realites.com.tn\/fr\/wp-json\/wp\/v2\/media\/191918"}],"wp:attachment":[{"href":"https:\/\/realites.com.tn\/fr\/wp-json\/wp\/v2\/media?parent=191917"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/realites.com.tn\/fr\/wp-json\/wp\/v2\/categories?post=191917"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/realites.com.tn\/fr\/wp-json\/wp\/v2\/tags?post=191917"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}