{"id":214848,"date":"2021-07-08T18:26:10","date_gmt":"2021-07-08T17:26:10","guid":{"rendered":"https:\/\/www.realites.com.tn\/?p=214848"},"modified":"2021-07-08T18:26:10","modified_gmt":"2021-07-08T17:26:10","slug":"covid-19-le-tocilizumab-est-efficace-confirme-loms","status":"publish","type":"post","link":"https:\/\/realites.com.tn\/fr\/covid-19-le-tocilizumab-est-efficace-confirme-loms\/","title":{"rendered":"Covid-19: le tocilizumab est efficace, confirme l&rsquo;OMS"},"content":{"rendered":"<div>Une \u00e9tude affirme que cet anticorps monoclonal r\u00e9duit la mortalit\u00e9 face au Covid-19. En f\u00e9vrier d\u00e9j\u00e0, l&rsquo;essai clinique Recovery d\u00e9montrait ses propri\u00e9t\u00e9s face aux formes s\u00e9v\u00e8res de la maladie.<\/div>\n<div>Syndrome de d\u00e9tresse respiratoire aigu\u00eb, insuffisance r\u00e9nale, troubles du rythme cardiaque ou septic\u00e9mie, les formes graves li\u00e9es au Covid-19 sont nombreuses et vari\u00e9es. Bonne nouvelle sur ce front, les soignants disposent depuis le mois de f\u00e9vrier d\u2019un nouveau traitement pour r\u00e9duire la mortalit\u00e9 li\u00e9e au coronavirus: le tocilizumab.<\/div>\n<div>Cet anticorps monoclonal a \u00e9t\u00e9 plac\u00e9 sous le statut d\u2019autorisation temporaire d\u2019utilisation (ATU) de cohorte pour traiter les patients adultes \u00e0 risque \u00e9lev\u00e9 de d\u00e9velopper une forme grave du Covid. Il r\u00e9duit effectivement le risque de d\u00e9c\u00e8s chez les patients hospitalis\u00e9s, selon une nouvelle \u00e9tude publi\u00e9e mardi et portant sur pr\u00e8s de 11.000 patients.<\/div>\n<div>Le tocilizumab, administr\u00e9 par intraveineuse, avait pr\u00e9sent\u00e9 des r\u00e9sultats mitig\u00e9s lors de divers essais cliniques de moins grande ampleur, mais cette \u00e9tude, publi\u00e9e dans la revue scientifique JAMA, compile les r\u00e9sultats de 27 essais cliniques dans 28 pays. Elle est la premi\u00e8re \u00e0 porter sur un nombre si important de personnes.<\/div>\n<div>L\u2019Organisation mondiale de la sant\u00e9 (OMS) a ainsi recommand\u00e9 leur usage, en m\u00eame temps que des cortico\u00efdes comme la dexamethasone, chez les patients atteints de cas graves de Covid-19, a-t-elle annonc\u00e9. Cet avis confirme les r\u00e9sultats de l\u2019important essai clinique Recovery publi\u00e9s en f\u00e9vrier, concernant le tocilizumab.<\/div>\n<div><\/div>\n<div><strong>*Un \u201d\u00e9l\u00e9ment de preuve d\u00e9finitif\u201d<\/strong><\/div>\n<div>La nouvelle analyse a port\u00e9 sur les anticorps monoclonaux sarilumab et tocilizumab, des m\u00e9dicaments utilis\u00e9s \u00e0 l\u2019origine contre la polyarthrite rhumato\u00efde. On les appelle des antagonistes de l\u2019interleukine 6, car ils bloquent le r\u00e9cepteur de cette prot\u00e9ine. Or celle-ci joue un r\u00f4le dans le processus de surr\u00e9action immunitaire parfois d\u00e9clench\u00e9 par le coronavirus, entra\u00eenant une hyperinflammation responsable des cas les plus graves de Covid-19.<\/div>\n<div>Parmi les patients hospitalis\u00e9s, administrer l\u2019un de ces deux m\u00e9dicaments en m\u00eame temps que des cortico\u00efdes a r\u00e9duit le risque de d\u00e9c\u00e8s de 17%, compar\u00e9 \u00e0 l\u2019usage de cortico\u00efdes seuls. Les cortico\u00efdes comme la dexam\u00e9thasone, qui ont eux aussi un effet anti-inflammatoire, ont \u00e9t\u00e9 le premier traitement \u00e0 prouver leur efficacit\u00e9 sur la mortalit\u00e9 due au Covid-19.<\/div>\n<div>Dans le d\u00e9tail, cette \u00e9tude a analys\u00e9 l\u2019\u00e9tat de 10.930 patients, dont 6449 ont re\u00e7u le traitement (sarilumab ou tocilizumab), et 4.481 des soins habituels ou un placebo. Le risque de d\u00e9c\u00e8s au bout de 28 jours parmi le groupe ayant re\u00e7u le traitement \u00e9tait de 22%, contre 25% pour les autres. En isolant seulement les personnes ayant re\u00e7u simultan\u00e9ment le traitement et des cortico\u00efdes, le risque de d\u00e9c\u00e8s tombait m\u00eame \u00e0 21%.<\/div>\n<div>Selon son auteur principal, Manu Shankar-Hari, professeur au King\u2019s College de Londres, il s\u2019agit d\u2019un \u201d\u00e9l\u00e9ment de preuve d\u00e9finitif\u201d. Par ailleurs, le risque de devoir avoir recours \u00e0 un respirateur artificiel \u00e9tait \u00e9galement diminu\u00e9 avec le traitement.<\/div>\n<div>\u201cLa science a fait son travail, nous devons maintenant tourner notre attention vers les questions d\u2019acc\u00e8s\u201d, a d\u00e9clar\u00e9 Janet Diaz, responsable de l\u2019OMS cit\u00e9e dans un communiqu\u00e9. \u201cCompte tenu des in\u00e9galit\u00e9s mondiales pour les vaccins, les gens dans les pays les plus pauvres sont les plus expos\u00e9s aux cas graves de Covid-19. Ce sont eux que ces m\u00e9dicaments doivent atteindre.\u201d Une ambition \u00e0 pond\u00e9rer, puisque les anticorps monoclonaux sont chers, temporaires et contraignants. Ils interviennent principalement \u00e0 un moment critique de la maladie.(AFP)<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Une \u00e9tude affirme que cet anticorps monoclonal r\u00e9duit la mortalit\u00e9 face au Covid-19. En f\u00e9vrier d\u00e9j\u00e0, l&rsquo;essai clinique Recovery d\u00e9montrait ses propri\u00e9t\u00e9s face aux formes s\u00e9v\u00e8res de la maladie. Syndrome&hellip;<\/p>\n","protected":false},"author":60,"featured_media":214849,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[2515],"tags":[],"class_list":["post-214848","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sante"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Covid-19: le tocilizumab est efficace, confirme l&#039;OMS - R\u00e9alit\u00e9s Magazine<\/title>\n<meta name=\"description\" content=\"Une \u00e9tude affirme que cet anticorps monoclonal r\u00e9duit la mortalit\u00e9 face au Covid-19. 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